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NFL Players Association and Cleveland Clinic team up to tackle brain disease

The collaborative research hopes to not only improve the well-being of former NFL players, but to enhance cognitive well-being among athletes in general.

CLEVELAND — In an effort to improve the wellness of its players – past, present and future – the National Football League Players Association has announced that it has teamed up with Cleveland Clinic on a joint initiative to improve brain health.

The goal is to improve diagnosis, prediction of disease progression and help guide treatments. The collaborative research hopes to not only improve the well-being of former NFL players, but to enhance cognitive well-being among athletes in general and the larger community.

“Neurological diseases, such as Parkinson’s and Alzheimer’s, have become public health emergencies as our population ages, and they also are of utmost importance to the NFLPA,” said the initiative’s principal investigator, Jay Alberts, Ph.D., of Cleveland Clinic’s Lerner Research Institute and vice chair of Innovation for the Neurological Institute. “This collaborative research project will use machine learning techniques to address fundamental gaps in our understanding of disease processes and management. An ultimate goal of the initiative is for the created algorithms to support earlier diagnosis of neurological syndromes, enable better prediction of disease course and help guide interventions.”

According to a release, NFLPA and Cleveland Clinic collaborators will develop Explainable Artificial Intelligence (XAI) models while using machine learning tools and sources of data, such as demographics, patient-entered data, imaging and labs. When applied along with disease progression modeling, long-term pathological trajectories can be revealed from short-term clinical data, resulting in the development of transformative advances in the area of cognitive health.

The use of XAI techniques and machine learning tools will offer an opportunity to build models using patients who did not play professional football while still informing potential prevention and treatment programs for the benefit of the current and former player population. Outside of football, researchers believe the models will aid in the care and treatment of individuals in rural and underserved communities.

“This partnership with Cleveland Clinic is an exciting extension of our union’s ongoing commitment to advancing the physical and mental health of our player members,” said NFLPA Executive Director DeMaurice Smith. “As the physician community learns more about neurological disease through the resulting clinical decision-support tools, the better informed we will be in providing education and safety initiatives for professional football players.”

The NFLPA and Cleveland Clinic say they also seek to engage other partners in the medical and analytic space, creating a coordinated research network that will evaluate and conduct phased research projects. 

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Editor's Note: The below story aired on October 11, 2019

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